PRP vs. PRF: Understanding the Next Generation of Regenerative Aesthetics at The York Skin Clinic

At The York Skin Clinic, our "Age Well" philosophy is powered by the most advanced regenerative treatments available. When it comes to stimulating deep tissue repair, collagen production, and rejuvenation—whether for the skin or hair—we turn to the power of your own biology. Two leading, cutting-edge treatments are Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF). While both utilise the growth factors in your blood, they work in fundamentally different ways.

Here is a breakdown of these two remarkable treatments and the key differences that guide our bespoke treatment plans.Platelet-Rich Plasma (PRP)

What is PRP?

Platelet-Rich Plasma (PRP) is an autologous plasma (meaning it comes from your own body) that contains a high concentration of platelets. These platelets are naturally rich in growth factors—signalling proteins that actively stimulate tissue repair, collagen production, and rejuvenation in the skin or hair follicles.

The Science of PRP:

PRP is prepared by drawing a small sample of blood and placing it in a centrifuge. This high-speed process, which uses an anticoagulant to keep the sample liquid, separates the blood components, leaving us with plasma that contains a platelet concentration four to five times higher than normal blood.

The resulting liquid PRP provides a fast, short burst of growth factors. This makes it excellent for quick stimulation and general rejuvenation across various treatment areas. Perfect for Hair growth and pre and post hair transplant.

Platelet-Rich Fibrin (PRF)

What is PRF?

Platelet-Rich Fibrin (PRF) represents the second generation of platelet concentrates. Unlike PRP, PRF is processed without the use of anticoagulants. This allows a fibrin matrix to naturally form as the blood clots, trapping a high concentration of platelets and leukocytes (white blood cells).

The Science of PRF:

PRF is prepared using a lower-speed spin. This processing method allows the body's natural fibrin to form a three-dimensional scaffold. This scaffold acts as a "smart release" reservoir, allowing for a slow, sustained release of growth factors over a longer period.

The sustained release from the fibrin matrix makes PRF an exceptional option for better long-term regeneration, addressing overall skin texture, and treating delicate areas like the under-eyes.The Key Difference: Speed vs. Sustained Release

Perfect for around the eyes.

The main difference between PRP and PRF lies in their structure and the resulting rate of growth factor release:

Feature

PRP (Platelet-Rich Plasma)

PRF (Platelet-Rich Fibrin)

Preparation

Higher-speed spin with anticoagulant

Low-speed spin without anticoagulant

Structure

Liquid plasma with concentrated platelets

Fibrin matrix with concentrated platelets + leukocytes

Growth Factor Release

Fast, short burst of growth factors

Slow, sustained release of growth factors

Best For

Quick stimulation, general rejuvenation

Long-term regeneration, delicate areas

By understanding these nuances, our specialists at The York Skin Clinic can select the perfect regenerative treatment—be it PRP or PRF—to help you achieve your aesthetic and hair restoration goals. We tailor every plan to ensure maximum cosmetic improvement and enduring, natural results.